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Three teams in London, Edinburgh and Newcastle are to submit simultaneous applications to the Human Fertilisation and Embryology Authority this month, requesting licences to create early-stage "chimeric" embryos that will be 99.9% human and 0.1% rabbit or cow. The HFEA has sought legal advice and encouraged the applications.
The licences will allow scientists to remove the nuclei from animal eggs and replace them with human cells, leading to embryos containing the complete set of human genes, plus dozens of animal genes that sit inside tiny energy-making structures called mitochondria.
Two of the groups, led by Stephen Minger at King's College, London, and Ian Wilmut, the Edinburgh University scientist whose team created Dolly the Sheep, plan to use the embryos to create stem cells that carry the genetic defects responsible for neurological conditions such as motor neurone disease. By converting the stem cells into neurons, the...